3-[[[(4-Chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-N-pentyl-1-pyrrolidinecarboxamide

Name	SR9011
Synonyms	SR9011 Stenabolic Sr9011 3-[[[(4-Chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-N-pentyl-1-pyrrolidinecarboxamide
CAS	1379686-29-9

Molecular Formula	C23H31ClN4O3S
Molar Mass	479.0352
Density	1.254±0.06 g/cm3(Predicted)
Boling Point	642.8±50.0 °C(Predicted)
Solubility	DMSO: ≥ 43 mg/mL
Storage Condition	-20℃
Physical and Chemical Properties	Bioactive SR9011 is a Rev-erbα/β agonist with IC50s of 790 nM and 560 nM for Rev-erbα and rev-erbβ, respectively.
Use	Myocardial infarction is one of the most lethal cardiovascular diseases. Myocardial infarction is due to coronary artery stenosis or spasm, resulting in myocardial acute or persistent ischemia and hypoxia, myocardial cell death. Many pro-inflammatory cells, such as interleukin-1 beta (IL-1β) and tumor necrosis factor-alpha (TNF-α), are involved in myocardial remodeling due to chemical book3. SR9011 is a Rev-erb alpha/beta agonist, a member of the nuclear receptor family, which has been found to regulate the metabolism of biological tissues. The study found that SR9011 plays an important role in the regulation of autophagy gene rhythm in zebrafish.

Last Update：2024-01-02 23:10:35

3-[[[(4-Chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-N-pentyl-1-pyrrolidinecarboxamide Request for Quotation